New Research Institute Established at SPbSPU

The new nanobiotechnology special­ized research and education center was founded as part of SPbSPU in 2008 to deal fully with modern problems of nano­biotechnology.


Its equipment is paid for by combined financing from two Federal Devel­opment Programs “Innovation Universities” and “Development of Nanoindustry in the Russian Federation”. The total amount of in­vestment exceeds 250 million rubles.


Having reached the status of a Feder­al Research University, SPbSPU regards nanobiotechnology research as one of the priority fields for its research work. The Science and Research Institute of Nanobiotechnology (SRI “NanoBio”) was established under the United Science and Technology Research Institute. Both structures were founded in December of 2010. M.A. Khodorkovsky, PhD, Head of the Nanobiotechnologies Research and Education Center, is also the Chief Exec­utive Officer of NanoBio RI.


The Nanobiotechnologies Research and Education Center under NanoBio RI is now equipped with the most up-to-date equipment, including the Laser Tweezers integrated plant for research in nanobio­system dynamics, spectrometers for both visible and ultraviolet spectra, equipment for preparing biological samples for analy­sis, and so on.

As M.A. Khodorkovsky says, “…the equipment is sufficient for the most com­plicated identification of high-molecular and biological compounds with the high­est resolution and sensitivity. The Laser Tweezers plant is able to detect a single molecule of a biological compound. This means that new horizons have been es­tablished in the research and treatment of cancer, Alzheimer’s, and other diseases.”


The specialists of the Nanobiotechnolo­gies Research and Education Center are busy with the elaboration of new innova­tive products. They have worked out a set of mass-spectrometric, chromatographic, and electrophoretic methods of bioactive substance detection in human bodily flu­ids. They have also elaborated new meth­ods for pharmacological, endocrinologi­cal, oncological, and urological research and analysis, and for the diagnosis and treatment of cardio-neurologic diseases and mental disorders. The LC-IT-TOF-MS mass spectrometer (of Japanese origin) is used for therapeutic drug monitoring, drug therapy monitoring, and biomarker detection in human blood, urine, saliva, brain tissue, and other tissues. The spe­cialists at the center also investigate the bioequivalence of drugs and investigate methods for the quantification of bioactive compounds. They also carry out medical, ecological and pharmacological applied research.


One of the fields of the center’s work is research into HIV treatment. The center’s specialists try to model HIV transcription for detection of new molecular targets. The targets should indicate the low level of mutations under the influence of drugs.


The center’s specialists have already de­veloped technologies for cancer diagnosis and monitoring. The Laser Tweezers plant is used for research on laser, electromag­netic, and other influences on living cells. It is also used for research on normal and pathological patterns of cell division, in­cluding cancer cell division. The plant is also useful for microsurgery on living cells. The Laser Tweezers are also used for non-biological nanostructure analysis.


The center collaborates with leading Rus­sian higher education and research in­stitutions such as Saint Petersburg State Medical University, Saint Petersburg State University, Pavlov Institute of Physiology the Polymer Research Institute of the Rus­sian Academy, the Analytical Instrument and Cytology Research Institutes of the Russian Academy, the All-Russian Center of Emergency and Radiation Medicine of the MEM of Russia, Lumex Ltd., and so on. Under the Research Program by the Federal Agency for Science and Inno­vation, the center collaborates with such foreign research institutions as Howard University (USA), the University of Tou­louse (France), Uppsala University (Swe­den), and the Norwegian University of Science and Technology (Trondheim, Nor­way).

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